Yeast Gup1(2) Proteins Are Homologues of the Hedgehog Morphogens Acyltransferases HHAT(L): Facts and Implications

作者: Cândida Lucas , Célia Ferreira , Giulia Cazzanelli , Ricardo Franco-Duarte , Joana Tulha

DOI: 10.3390/JDB4040033

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摘要: In multiple tissues, the Hedgehog secreted morphogen activates in receiving cells a pathway involved cell fate, proliferation and differentiation cells. This is particularly important during embryogenesis. The protein HHAT (Hedgehog O-acyltransferase) modifies Hh morphogens prior to their secretion, while HHATL (Hh O-acyltransferase-like) negatively regulates pathway. are homologous Saccharomyces cerevisiae Gup2 Gup1, respectively. yeast, Gup1 associated with high number diversity of biological functions, namely polarity establishment, secretory/endocytic functionality, vacuole morphology wall membrane composition, structure maintenance. Phenotypes underlying death, morphogenesis also included. Paracrine signalling, like one promoted by pathway, has not been shown occur microbial communities, despite fact that large aggregates biofilms or colonies behave as proto-tissues. Instead, these have suggested sense population density through secretion quorum-sensing chemicals. review focuses on Gup1/HHATL Gup2/HHAT proteins. We functions physiology proteins yeasts higher eukaryotes. suggest standardisation presently chaotic Gup-related nomenclature, which includes KIAA117, c3orf3, RASP, Skinny, Sightless Central Missing, order avoid disclosure otherwise unnoticed information.

参考文章(230)
Fábio Faria-Oliveira, Joana Carvalho, Celso LR Belmiro, Montserrat Martinez-Gomariz, Maria Luisa Hernaez, Mauro Pavão, Concha Gil, Cândida Lucas, Célia Ferreira, None, Methodologies to generate, extract, purify and fractionate yeast ECM for analytical use in proteomics and glycomics. BMC Microbiology. ,vol. 14, pp. 244- 244 ,(2014) , 10.1186/S12866-014-0244-0
Morihisa Fujita, Reika Watanabe, Nina Jaensch, Maria Romanova-Michaelides, Tadashi Satoh, Masaki Kato, Howard Riezman, Yoshiki Yamaguchi, Yusuke Maeda, Taroh Kinoshita, Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI Journal of Cell Biology. ,vol. 194, pp. 61- 75 ,(2011) , 10.1083/JCB.201012074
Kyung Ok Yu, Seung Wook Kim, Sung Ok Han, Engineering of glycerol utilization pathway for ethanol production by Saccharomyces cerevisiae. Bioresource Technology. ,vol. 101, pp. 4157- 4161 ,(2010) , 10.1016/J.BIORTECH.2010.01.066
H. Tian, C. A. Callahan, K. J. DuPree, W. C. Darbonne, C. P. Ahn, S. J. Scales, F. J. de Sauvage, Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 4254- 4259 ,(2009) , 10.1073/PNAS.0813203106
Christer Larsson, Inga-Lill Påhlman, Ricky Ansell, Michel Rigoulet, Lennart Adler, Lena Gustafsson, The importance of the glycerol 3‐phosphate shuttle during aerobic growth of Saccharomyces cerevisiae Yeast. ,vol. 14, pp. 347- 357 ,(1998) , 10.1002/(SICI)1097-0061(19980315)14:4<347::AID-YEA226>3.0.CO;2-9
Shaorong Chong, Yang Shao, Henry Paulus, Jack Benner, Francine B. Perler, Ming-Qun Xu, Protein Splicing Involving the Saccharomyces cerevisiae VMA Intein THE STEPS IN THE SPLICING PATHWAY, SIDE REACTIONS LEADING TO PROTEIN CLEAVAGE, AND ESTABLISHMENT OF AN IN VITRO SPLICING SYSTEM Journal of Biological Chemistry. ,vol. 271, pp. 22159- 22168 ,(1996) , 10.1074/JBC.271.36.22159
Sunil S. Karhadkar, G. Steven Bova, Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T. Isaacs, David M. Berman, Philip A. Beachy, Hedgehog signaling in prostate regeneration neoplasia and metastasis Nature. ,vol. 431, pp. 707- 712 ,(2004) , 10.1038/NATURE02962