作者: Cândida Lucas , Célia Ferreira , Giulia Cazzanelli , Ricardo Franco-Duarte , Joana Tulha
DOI: 10.3390/JDB4040033
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摘要: In multiple tissues, the Hedgehog secreted morphogen activates in receiving cells a pathway involved cell fate, proliferation and differentiation cells. This is particularly important during embryogenesis. The protein HHAT (Hedgehog O-acyltransferase) modifies Hh morphogens prior to their secretion, while HHATL (Hh O-acyltransferase-like) negatively regulates pathway. are homologous Saccharomyces cerevisiae Gup2 Gup1, respectively. yeast, Gup1 associated with high number diversity of biological functions, namely polarity establishment, secretory/endocytic functionality, vacuole morphology wall membrane composition, structure maintenance. Phenotypes underlying death, morphogenesis also included. Paracrine signalling, like one promoted by pathway, has not been shown occur microbial communities, despite fact that large aggregates biofilms or colonies behave as proto-tissues. Instead, these have suggested sense population density through secretion quorum-sensing chemicals. review focuses on Gup1/HHATL Gup2/HHAT proteins. We functions physiology proteins yeasts higher eukaryotes. suggest standardisation presently chaotic Gup-related nomenclature, which includes KIAA117, c3orf3, RASP, Skinny, Sightless Central Missing, order avoid disclosure otherwise unnoticed information.