Three-Tiered versus Two-Tiered Classification of Squamous Dysplasia in Cervical Cytology: Results of a Follow-Up Study.
作者： Katrin Marquardt , Peter Ziemke , Konrad Neumann
DOI: 10.1159/000494984
关键词:
摘要: Objective: Regarding cytological findings of squamous dysplasia, a comparison was made between three-tiered classification – low-grade intraepithelial lesion (LSIL), high-grade SIL/cervical neoplasia 2 (HSIL/CIN2), and HSIL/CIN3 two-tiered LSIL HSIL. The respective risk for CIN2+ CIN3+ calculated to make decisions regarding management. Methods: A total 2,949 women with first-time cytologic dysplasia (LSIL, HSIL/CIN2, or HSIL/CIN3) January 2013 June 2016 were enrolled. Subsequent histological diagnoses evaluated until August 2018. For each category findings, the determined by Kaplan-Meier estimates. differences in categories checked significance using log-rank test. Results: LSIL, HSIL/CIN3, after 12, 24, 60 months 3.4, 9.4, 23.3%; 35.2, 44.8, 59.8%; 95.5, 97.8, 98.9%, respectively. 2.0, 5.5, 13.5%; 28.6, 35.6, 48.3%; 91.3, 95.6, 97.9%, are highly significant, respectively (p < 0.001). Conclusion: such as Munich Nomenclature III cytology is suitable risk-adapted clinical management, especially avoid overdiagnosis overtreatment.
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