Understanding the Role of Metal Ions in RNA Folding and Function: Lessons from RNase P, a Ribonucleoprotein Enzyme
作者： Michael E. Harris , Eric L. Christian
DOI: 10.1007/978-3-540-70840-7_9
关键词:
摘要: There is a large and rapidly growing literature relating RNA function to metal ion identity concentration; however, due the complexity number of interactions it remains significant experimental challenge tie individual ions specific aspects function. Investigation ribonculeopro- tein enzyme RNase P has assisted in defining characteristics RNA-metal provided useful model system for understanding catalysis ribonucleoprotein assembly. The goal this chapter review progress under- standing physical basis functional with relate development our general. research results reviewed here encompass: (1) Determination contribution divalent binding function, (2) Identification sites their (3) effect protein on affinity.
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Evert Nieboer, The lanthanide ions as structural probes in biological and model systems Springer Berlin Heidelberg. pp. 1- 47 ,(1975) , 10.1007/BFB0116554
L.A. Kirsebom, S.G. Svärd, Base pairing between Escherichia coli RNase P RNA and its substrate. The EMBO Journal. ,vol. 13, pp. 4870- 4876 ,(1994) , 10.1002/J.1460-2075.1994.TB06814.X
Sean P. Ryder, Lori Ortoleva-Donnelly, Anne B. Kosek, Scott A. Strobel, [6] Chemical probing of RNA by nucleotide analog interference mapping Methods in Enzymology. ,vol. 317, pp. 92- 109 ,(2000) , 10.1016/S0076-6879(00)17008-9
Anna Marie Pyle, Roland K. O. Sigel, Anand Vaidya, Metal ion binding sites in a group II intron core. Nature Structural & Molecular Biology. ,vol. 7, pp. 1111- 1116 ,(2000) , 10.1038/81958
W.W. Cleland, [13] Isotope effects: Determination of enzyme transition state structure Methods in Enzymology. ,vol. 249, pp. 341- 373 ,(1995) , 10.1016/0076-6879(95)49041-8
Hugh D. Robertson, Sidney Altman, John D. Smith, Purification and Properties of a Specific Escherichia coli Ribonuclease which Cleaves a Tyrosine Transfer Ribonucleic Acid Precursor Journal of Biological Chemistry. ,vol. 247, pp. 5243- 5251 ,(1972) , 10.1016/S0021-9258(19)44963-6
K J Gardiner, T L Marsh, N R Pace, Ion dependence of the Bacillus subtilis RNase P reaction. Journal of Biological Chemistry. ,vol. 260, pp. 5415- 5419 ,(1985) , 10.1016/S0021-9258(18)89038-X
D Smith, A B Burgin, E S Haas, N R Pace, Influence of metal ions on the ribonuclease P reaction. Distinguishing substrate binding from catalysis. Journal of Biological Chemistry. ,vol. 267, pp. 2429- 2436 ,(1992) , 10.1016/S0021-9258(18)45897-8
L. Claus S. Vörtler, Fritz Eckstein, Phosphorothioate modification of RNA for stereochemical and interference analyses. Methods in Enzymology. ,vol. 317, pp. 74- 91 ,(2000) , 10.1016/S0076-6879(00)17007-7
Carol A. Fierke, Gordon G. Hammes, [1] Transient kinetic approaches to enzyme mechanisms Methods in Enzymology. ,vol. 249, pp. 3- 37 ,(1995) , 10.1016/0076-6879(95)49029-9