作者: Néstor Gustavo Pérez
DOI: 10.1007/978-1-4615-0355-2_20
关键词:
摘要: When the heart is subjected to a brief but severe episode of ischemia, prolonged contractile dysfunction becomes evident upon reperfusion, despite absence irreversible tissue damage. This acute and fully reversible form pump failure has been called “myocardial stunning” characterized by decreased myofilament Ca2+ responsiveness, because selective Ca2+-activated troponin I proteolysis during early reperfusion. Interestingly, when pretreated with one or more short cycles ischemia-reperfusion, paradoxical protection against subsequent ischemic takes place. protective effect known as preconditioning preservation responsiveness Ca2+.