Myofilament Calcium Responsiveness in Stunning and Preconditioning

作者: Néstor Gustavo Pérez

DOI: 10.1007/978-1-4615-0355-2_20

关键词:

摘要: When the heart is subjected to a brief but severe episode of ischemia, prolonged contractile dysfunction becomes evident upon reperfusion, despite absence irreversible tissue damage. This acute and fully reversible form pump failure has been called “myocardial stunning” characterized by decreased myofilament Ca2+ responsiveness, because selective Ca2+-activated troponin I proteolysis during early reperfusion. Interestingly, when pretreated with one or more short cycles ischemia-reperfusion, paradoxical protection against subsequent ischemic takes place. protective effect known as preconditioning preservation responsiveness Ca2+.

参考文章(33)
E.E. McKee, J.Y. Cheung, D.E. Rannels, H.E. Morgan, Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine. Journal of Biological Chemistry. ,vol. 253, pp. 1030- 1040 ,(1978) , 10.1016/S0021-9258(17)38107-3
Susana M. Mosca, Ricardo J. Gelpi, Jose Milei, Graciela Fernández Alonso, Horacio E. Cingolani, Is stunning prevented by ischemic preconditioning Molecular and Cellular Biochemistry. ,vol. 186, pp. 123- 129 ,(1998) , 10.1023/A:1006879616265
A.F. Martin, Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I. Journal of Biological Chemistry. ,vol. 256, pp. 964- 968 ,(1981) , 10.1016/S0021-9258(19)70073-8
F Di Lisa, R De Tullio, F Salamino, R Barbato, E Melloni, N Siliprandi, S Schiaffino, S Pontremoli, Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. Biochemical Journal. ,vol. 308, pp. 57- 61 ,(1995) , 10.1042/BJ3080057
Wei Dong Gao, Dan Atar, Yongge Liu, Nestor Gustavo Perez, Anne M. Murphy, Eduardo Marban, Role of Troponin I Proteolysis in the Pathogenesis of Stunned Myocardium Circulation Research. ,vol. 80, pp. 393- 399 ,(1997) , 10.1161/01.RES.0000435855.49359.47
H Kusuoka, J K Porterfield, H F Weisman, M L Weisfeldt, E Marban, Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. Journal of Clinical Investigation. ,vol. 79, pp. 950- 961 ,(1987) , 10.1172/JCI112906
Anne M Murphy, Harald Kogler, Dimitrios Georgakopoulos, Jason L McDonough, David A Kass, Jennifer E Van Eyk, Eduardo Marbán, Transgenic mouse model of stunned myocardium. Science. ,vol. 287, pp. 488- 491 ,(2000) , 10.1126/SCIENCE.287.5452.488
Néstor Gustavo Pérez, Eduardo Marbán, Horacio E Cingolani, Preservation of myofilament calcium responsiveness underlies protection against myocardial stunning by ischemic preconditioning Cardiovascular Research. ,vol. 42, pp. 636- 643 ,(1999) , 10.1016/S0008-6363(98)00299-5
Yuwei Li, Peter Whittaker, Robert A. Kloner, The transient nature of the effect of ischemic preconditioning on myocardial infarct size and ventricular arrhythmia. American Heart Journal. ,vol. 123, pp. 346- 353 ,(1992) , 10.1016/0002-8703(92)90645-C