Consumption of a Branched-Chain Amino Acid (BCAA) during Days 2–10 of Pregnancy Causes Abnormal Fetal and Placental Growth: Implications for BCAA Supplementation in Humans

摘要: A relatively large branched-chain amino acid (BCAA) supplement, consumed for more than 10 days, appears to be especially effective at alleviating muscle damage and soreness during intense human training. However, perturbations in protein consumption could have unwanted transgenerational effects on male female reproduction. This paper hypothesizes that isoleucine by mice from days 2 of pregnancy will alter fetal placental growth later gestation. Mice had received 118 mM their drinking water delivered pups day 19 were 9% larger normal, whereas the reverse was true born 20. Moreover, inverse correlation between birth weight litter size lost previously excess isoleucine. Similarly, normal correlations weights 18 placentas smaller than, fetuses pregnancy, but 15. Other unintended unexpected BCAA should studied thoroughly due increasing use BCAAs alleviate athletes.