Magnetically-guided assembly of magnetic sugar particles for biodegradable scaffolds

摘要: Recent advances to develop scaffolds with controlled pore layout and porosity have great significance in tissue engineering for providing optimal cultivation conditions. Porogen leaching has been commonly used control size, structure the scaffold fabrication. This paper reports a magnetic steering method controlling sugar particles as porogens fabrication of sheet-like scaffold. A patterning device is utilized align on desired positions PVA introduced improve pores. After Poly(L-lactide-co-e-caprolactone) (PLCL) casting removal template, spherical pores are generated inside The surface inner morphologies evaluated aid optical microscope scanning electron microscope, respectively. results show controllable diameters ranges 150μm 200μm appropriate interconnection pores, elegant wall morphology high achieved small-size size 8mm width 10mm length.