Immune mechanisms of the occupational sensitization with methylen-dyphenyl diisocyanate (MDI)

摘要: The aim of this study was to objectify and clarity some mechanisms the immune response professional sensitization with MDI. 26 workers were tested for immediate type (ST a broad set indoor allergens serum MDI-IgE) delayed standard battery antigens cellular immunity MDI), also lymphocyte sub-populations their functional state by flow cytometric analysis. most frequent allergic complaints were: rhinits (70 %), skin manifestations (53 conjunctivitis (35 %) initial bronchial asthma in two cases (12 %). We found 41 % normal reactivity all tested. Specific MDI 28.5 - 70 complaints. laboratory indices suggest prevalence cell mediated symptoms production INF gamma, responding stimulation deficient or insignificant IL-4, as well linear correlation between data CMI, IL-4. Our results participation more than one mechanism injury clinically manifested reactions.