Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

摘要: Proto-oncogenes encode proteins with three main sites of action: the cell-surface membrane, cytoplasm and nucleus. Although exact biochemical function most proto-oncogene products is not understood, several them are known to be involved in signal transduction. A role gene regulation through DNA binding has been suggested for a recently isolated member group oncogenes acting at nucleus, v-jun. The C-terminus putative v-jun-encoded protein similar sequence yeast transcriptional activator GCN4 (refs 8, 9), which forms its minimal DNA-binding domain. binds specific whose consensus highly recognition mammalian AP-1 12, 13). Like GCN4, promoter elements genes activates their transcription. Because similarity between AP-1, we examined possibility that could product c-jun proto-oncogene. experimental results reported here indicate JUN oncoprotein sequence-specific AP-1.