Revisiting prostate cancer metabolism: From metabolites to disease and therapy

摘要: Prostate cancer (PCa), one of the most commonly diagnosed cancers worldwide, still presents important unmet clinical needs concerning treatment. In last years, metabolic reprogramming and specificities tumor cells emerged as an exciting field for therapy. The unique features PCa metabolism, activation specific pathways, propelled use inhibitors present work revises knowledge metabolism alterations that underlie development progression disease. A focus is given to role bioenergetic sources, namely, glucose, lipids, glutamine sustaining cell survival growth. Moreover, it described action oncogenes/tumor suppressors sex steroid hormones in PCa. Finally, status treatment based on inhibition pathways presented. Globally, this review updates landscape highlighting critical could have a therapeutic interest.