Serological profiles in nursery piglets colonized with Staphylococcus aureus

摘要: At present, the immune response of pigs in relation to Staphylococcus aureus carriage is poorly understood. This study was aimed at investigating dynamics anti-staphylococcal humoral methicillin-susceptible S. (MSSA)-positive piglets and assessing effect experimental introduction a methicillin-resistant (MRSA) Sequence Type (ST) 398 strain. Therefore, serum samples were collected different times from 31 weaned originating four sows. Twenty-four out challenged with MRSA ST398. The analyzed for IgG antibodies 39S. antigens, using multiplex bead-based assay (xMAP technology, Luminex Corporation). Though antibody responses showed broad inter-individual variability, serological results appeared be clustered by litter origin. For most an age-related observed apparent increase titers directed against staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMM), which have been shown play role colonization. In animals, toxins or immune-modulating proteins decreased age, possibly reflecting absence bacterial invasion.