A first comparative study of purpurinimide-based fluorinated vs. nonfluorinated photosensitizers for photodynamic therapy.
作者： Amy L. Gryshuk , Andrew Graham , Suresh K. Pandey , William R. Potter , Joseph R. Missert
DOI: 10.1562/0031-8655(2002)076<0555:AFCSOP>2.0.CO;2
关键词:
摘要: A first report on the synthesis and comparative in vitro-in vivo photosensitizing efficacy of various fluorinated corresponding nonfluorinated, purpurinimide-based photosensitizers is discussed. In preliminary screening, compared with nonfluorinated analogs, purpurinimides bearing trifluoromethyl substituents showed enhanced efficacy. Among compounds (isomers) similar lipophilicity, position was found to play a decisive role biological
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