Pain transduction: a pharmacologic perspective.
作者： Dan M. McEntire , Daniel R. Kirkpatrick , Nicholas P. Dueck , Mitchell J. Kerfeld , Tyler A. Smith
DOI: 10.1080/17512433.2016.1183481
关键词:
摘要: ABSTRACTIntroduction: Pain represents a necessary physiological function yet remains significant pathological process in humans across the world. The transduction of nociceptive stimulus refers to processes that turn noxious into transmissible neurological signal. This involves number ion channels facilitate conversion and electrical signal.Areas covered: An understanding physiology complements discussion analgesic pharmacology. Therefore, two are presented together. In this review article, critical evaluation is provided on research findings relating both pharmacology relevant acid-sensing (ASICs), transient receptor potential (TRP) cation channels, voltage-gated sodium (Nav) channels.Expert commentary: Despite steps toward identifying new more effective modalities treat pain, there remain many avenues inquiry related pain transduction. activity ...
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