Intact acquisition and long-term retention of mirror-tracing skill in Alzheimer's disease and in global amnesia.

摘要: The ability of patients with Alzheimer's disease (AD) or global amnesia (AMN) to acquire skill for tracing a pattern seen in mirror-revers ed view and retain that over 24-hr intervals was examined. Both patient groups had poor recall recognition their mirror-tracing experience, but they acquired retained as well normal control subjects. One AMN (H.M.) the year-long interval. Furthermore, transferred normally an alternate pattern. These results indicate memory system underlying learning is separable from medial-temporal structures compromised AD neocortical areas AD. Brain regions relatively spared early AD, such basal ganglia cerebellum, may mediate critical aspects novel sensorimotor associations underlie skilled mirror tracing. age-related neurodegenerative disorder impairs many domains cognition, especially new information. have impaired materials experiences even after delays short few seconds (e.g., Corkin, 1982). Experimental examinations patients, however, revealed intact certain kinds experience at least three domains. domain perceptual aftereffects McCollough effect (Savoy & Gabrieli, 1991). A second consists some repetition priming, which measured change processing stimulus because prior exposure Gabrieli et al., 1992, press; Keane, Fennema, Growdon,