Randomized comparison of vinorelbine and melphalan in anthracycline-refractory advanced breast cancer.
作者： S Jones , E Winer , C Vogel , L Laufman , L Hutchins
DOI: 10.1200/JCO.1995.13.10.2567
关键词:
摘要: PURPOSEThis prospective multicenter randomized trial was performed to compare the effectiveness and safety of intravenous (i.v.) vinorelbine tartrate (Navelbine [NVB]; Burroughs Wellcome Co, Research Triangle Park, NC) with i.v. melphalan (Alkeran [ALK]; Co) in a heavily pretreated population patients anthracycline-refractory advanced breast cancer (ABC). Efficacy end points included time disease progression (TDP), treatment failure (TTF), survival, tumor response rates, quality life (QL) relief cancer-related symptoms.PATIENTS AND METHODSBetween August 24, 1990, December 1, 1992, 183 were (2:1) NVB (30 mg/m2 weekly) or ALK (25 every 4 weeks) Patients stratified by measurable nonmeasurable-assessable center.RESULTSTime significantly longer than ALK, median 12 weeks versus 8 weeks, respectively (P < .001). also...
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