Clinical Pharmacology and Resistance to Dihydrofolate Reductase Inhibitors
作者： Richard Gorlick , Joseph R. Bertino
DOI: 10.1007/978-1-59259-725-3_3
关键词:
摘要: It has been almost 50 years since aminopterin, the first drug capable of inducing complete remissions in children with acute lymphoblastic leukemia (ALL), was tested (1). Methotrexate (MTX), also an antifolate inhibitor dihydrofolate reductase (DHFR), soon after replaced aminopterin clinic and is used widely not only for treatment various forms cancer, such as lymphoma, germ-cell tumors, breast head neck cancer but autoimmune diseases rheumatoid arthritis, psoriasis, prevention graft-vs-host disease (2). Al-though dramatic responses even cures are observed some malignancies MTX alone or combination, majority intrinsic resistance limits effectiveness. In that initially sensitive to therapy, e.g., ALL, acquired may develop, contributing failure relapse (3).
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