Experimental Study of the Effect of Helicobacter pylori Infection on Barrett Esophagus and Its Correlation with Immune Function

摘要: Background: Helicobacter pylori is an important pathogen in the upper digestive tract. It of great significance to properly understand risk factors for transformation Barrett esophagus into esophageal carcinoma. However, relationship between H. and gastroesophageal reflux disease (GERD) remains controversial, correlation with immune function has been rarely reported. Objectives: This study investigated effect infection on its function. Methods: We recruited 40 patients (Barrett group) GERD (GERD group). In addition, healthy controls were selected control group. Esophageal measured each Results: The positivity rate (P < 0.05) sphincter pressure lower both groups than group, while levels PGI, PGII, PGI/II, G-17 higher 0.05). CD3+, CD4+, CD4+/CD8+ group but they negatively correlated infection. level CD8+ was it positively Conclusions: may protect against by reducing gastric acid secretion increasing pressure. Besides, a certain