摘要: Die Eigenschaft der Opioide, Sucht und Abhangigkeit zu erzeugen, ist zum einen direkt proportional analgetischen Starke des jeweiligen Produkts, anderen hangt sie von mit dem Liganden interagierenden Rezeptorpopulation Kinetik am Rezeptor ab. Buprenorphin z. B. hat aufgrund langsamen Dissoziation vom ein geringeres Sucht- Abhangigkeitspotential als andere wirkstarke Opioide (Heel 1979). Desweiteren weisen sowohl die reinen x-Liganden, auch gemischt wirkenden Agonisten/Antagonisten wegen einer uber den x-Rezeptor vermittelnden Analgesie geringes Suchtpotential auf (Romer 1980; Schmidt 1985; Pircio 1976).
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