Drug-associated heat stroke.

摘要: During the June 1998 heat wave in New Orleans, 8 patients came to emergency department of a large public hospital over 14-day period. They were subsequently admitted intensive care unit with diagnosis stroke. On each these days, ambient temperature exceeded 33.3 degrees C (91.9 F). Although highest recorded was only 35.6 (96 F), index reached high 44.5 (112 Weather-related illnesses are well documented, but reports rarely address contributing medications or drugs. In this series, 6 (75%) had been using medication drugs known induce worsen hyperthermia. A seventh patient prescribed phenothiazine, actual use could not be established. An eighth an unidentified agent detected on toxicologic screening. The most common drug identified cocaine. Other included diphenhydramine, tricyclic antidepressants, and phenothiazines. Six rhabdomyolysis; 3 them also disseminated intravascular coagulation. There 2 deaths, yielding 25% mortality rate.