WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome

摘要: Purpose: Wnt ligands play a major role in development and are important cancer. Expression microarray analysis correlates one member of this family, WNT5A, to subclass melanomas with increased motility invasion. There no large studies clinical samples primarily addressing the importance WNT5A melanoma progression or outcome. Therefore, study aimed assess protein expression during its effect on Experimental Design: was determined series 59 primary matched metastases. To provide benchmark against which p16 ink4a analyzed, as has been previously well documented melanoma. The outcome assessed 102 melanomas. Results: Cytoplasmic showed trend increasing ( P = 0.013), whereas there diminishing 0.006). Nevi relatively strong expression. Strong cytoplasmic an independent risk factor for reduced metastasis-free overall survival multivariate 0.001 0.003, respectively). Conclusion: increases is associated poor