Special pharmacology of the new sulfonylurea glimepiride.

摘要: Glimepiride (Hoe 490) is a new sulfonylurea. After oral administration of Hoe 490 to rabbits, blood glucose was lowered 3.5 times more than after glibenclamide (HB 419) and intravenous administration, 2.5 more. This superiority in efficacy demonstrated by onset, maximum duration action. In rats, has much shorter effect on HB 419, but the initial orally up 6 i.v. 2 stronger that 419. dogs, had considerably longer glucose-lowering However, only half as intense 419 first hours treatment initially thereafter temporarily distinctly weaker The rapid decrease dog accompanied correspondingly earlier higher plasma insulin increase. accordance with less there slower rise faster drop insulin. long action can, however, not be sufficiently explained values. isolated rat pancreas perfused glucose-free medium, released glucagon beside somatostatin. threshold concentration for secretion lower those somatostatin release.(ABSTRACT TRUNCATED AT 250 WORDS)