Synthesis of Azocino[5,4‐b]indoles via Gold‐Catalyzed Intramolecular Alkyne Hydroarylation
作者： Vsevolod A. Peshkov , Olga P. Pereshivko , Erik V. Van der Eycken
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摘要: An efficient procedure for the synthesis of azocino[5,4-b]indole framework is presented, relying on a cationic gold-catalyzed intramolecular alkyne hydroarylation propargylic amides derived from various tryptamines and 3-substituted 2-propynoic acids. The triphenylphosphinegold(I) chloride/silver(I) triflate catalytic system was found to be superior our previously described mercury(II) catalyst, hence substrate scope process significantly expanded.
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