Cardiovascular Status of Carriers of the Apolipoprotein A-IMilano Mutant The Limone sul Garda Study
作者： Cesare R. Sirtori , Laura Calabresi , Guido Franceschini , Damiano Baldassarre , Mauro Amato
DOI: 10.1161/01.CIR.103.15.1949
关键词:
摘要: Background—Carriers of the apolipoprotein A-IMilano (apoA-IM) mutant present with very low plasma HDL cholesterol and moderate hypertriglyceridemia, apparently not leading to premature coronary heart disease. The objective this study was establish whether high-risk lipid/lipoprotein profile is associated structural changes in carotid arteries heart, indicative preclinical atherosclerosis. Methods Results—Twenty-one A-IM carriers were compared age- sex-matched control subjects from same kindred 2 series matched primary hypoalphalipoproteinemia (HA). Structural defined as intima-media thickness (IMT) measured by B-mode ultrasound. HA subjects, both recruited among patients attending our Lipid Clinic blood donors, showed significant thickening carotids (average IMT, 0.86±0.25 0.88±0.29 mm, respectively) 0.64±0.12 mm); apoA-IM i...
elsevier.com
sci-hub.se 参考文章(36)
G Gianfranceschi, A Menotti, C R Sirtori, A Cerrone, V Gualandri, G Franceschini, G B Orsini, AIMilano apoprotein identification of the complete kindred and evidence of a dominant genetic transmission. American Journal of Human Genetics. ,vol. 37, pp. 1083- 1097 ,(1985)
G Gianfranceschi, C R Sirtori, G Franceschini, D Magani, G Vecchio, Apolipoprotein AIMilano. Accelerated binding and dissociation from lipids of a human apolipoprotein variant. Journal of Biological Chemistry. ,vol. 260, pp. 16321- 16325 ,(1985) , 10.1016/S0021-9258(17)36239-7
L Calabresi, G Vecchio, R Longhi, E Gianazza, G Palm, H Wadensten, A Hammarström, A Olsson, A Karlström, T Sejlitz, Molecular characterization of native and recombinant apolipoprotein A-IMilano dimer. The introduction of an interchain disulfide bridge remarkably alters the physicochemical properties of apolipoprotein A-I. Journal of Biological Chemistry. ,vol. 269, pp. 32168- 32174 ,(1994) , 10.1016/S0021-9258(18)31616-8
K H Weisgraber, S C Rall, T P Bersot, R W Mahley, G Franceschini, C R Sirtori, Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I Journal of Biological Chemistry. ,vol. 258, pp. 2508- 2513 ,(1983) , 10.1016/S0021-9258(18)32955-7
G R Warnick, J Benderson, J J Albers, Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clinical Chemistry. ,vol. 28, pp. 1379- 1388 ,(1982) , 10.1093/CLINCHEM/28.6.1379
G Franceschini, M Cassinotti, G Vecchio, G Gianfranceschi, F Pazzucconi, T Murakami, M Sirtori, A L D'Acquarica, C R Sirtori, PRAVASTATIN EFFECTIVELY LOWERS LDL CHOLESTEROL IN FAMILIAL COMBINED HYPERLIPIDEMIA WITHOUT CHANGING LDL SUBCLASS PATTERN Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 14, pp. 1569- 1575 ,(1994) , 10.1161/01.ATV.14.10.1569
C. Serfaty-Lacrosniere, F. Civeira, A. Lanzberg, P. Isaia, J. Berg, E.D. Janus, M.P. Smith, P.H. Pritchard, J. Frohlich, R.S. Lees, G.F. Barnard, J.M. Ordovas, E.J. Schaefer, Homozygous Tangier disease and cardiovascular disease Atherosclerosis. ,vol. 107, pp. 85- 98 ,(1994) , 10.1016/0021-9150(94)90144-9
P Roma, R E Gregg, M S Meng, R Ronan, L A Zech, G Franceschini, C R Sirtori, H B Brewer, In vivo metabolism of a mutant form of apolipoprotein A-I, apo A-IMilano, associated with familial hypoalphalipoproteinemia. Journal of Clinical Investigation. ,vol. 91, pp. 1445- 1452 ,(1993) , 10.1172/JCI116349
Maria Lorenza Muiesan, GianFranco Pasini, Massimo Salvetti, Silvia Calebich, Roberto Zulli, Maurizio Castellano, Damiano Rizzoni, Giorgio Bettoni, Angelo Cinelli, Enzo Porteri, Vittorio Corsetti, Enrico Agabiti-Rosei, Cardiac and vascular structural changes : Prevalence and relation to ambulatory blood pressure in a middle-aged general population in northern Italy : The Vobarno study Hypertension. ,vol. 27, pp. 1046- 1052 ,(1996) , 10.1161/01.HYP.27.5.1046
G Franceschini, C R Sirtori, A Capurso, K H Weisgraber, R W Mahley, A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family. Journal of Clinical Investigation. ,vol. 66, pp. 892- 900 ,(1980) , 10.1172/JCI109956