Systematic review and meta-analysis of hepatic arterial infusion chemotherapy as bridging therapy for colorectal liver metastases.
作者： Daniel L. Chan , Nayef A. Alzahrani , David L. Morris , Terence C. Chua
DOI: 10.1016/J.SURONC.2015.06.014
关键词:
摘要: Abstract Background Hepatic arterial infusion chemotherapy (HAIC) has been shown to be beneficial in the management of unresectable colorectal liver metastases (CRLM). This systematic review evaluates potential role HAIC as a neoadjuvant downstaging therapy, prior hepatic resection with curative intent for initially CRLM. Methods A literature search was conducted using Pubmed, EMBASE and Medline databases from January 2000 November 2013. Studies adopting bridging therapy CRLM were included. Results Eleven studies (n = 1514) response rate 50% achieved conversion surgery 18% patients. The median overall 5-year survival patients who underwent hepatectomy 53 months 49% compared 16 3% did not undergo surgery. Meta-analysis demonstrated strong association between improved (RR 0.56, 95% CI = 0.48–0.65, Z = 7.26, p Conclusion For presenting CRLM, conjunction current systemic may allow some potentially provide long-term survival.
elsevier.com
sci-hub.se 参考文章(62)
Caterina Accettura, Mario Bezzi, Enrico Cortesi, Andrea Mancuso, Bruno Massidda, Luca Paoluzzi, Rosa Giuliani, Marzia Palma, Fabiana Cecere, Giuliana D'Auria, Hepatic arterial continuous infusion (HACI) of oxaliplatin in patients with unresectable liver metastases from colorectal cancer. Anticancer Research. ,vol. 23, pp. 1917- 1922 ,(2003)
Shinichiro Koketsu, Isao Hirayama, Toshio Sawada, Masaru Kojima, Hiroyuki Horikoshi, Shigeru Tomozawa, Shinichi Sameshima, Toshiyuki Okada, Kenta Motegi, Youichi Kon, 5-Fluorouracil-related gene expression in hepatic artery infusion-treated patients with hepatic metastases from colorectal carcinomas. Anticancer Research. ,vol. 28, pp. 389- 393 ,(2008)
Lian-Xin Liu, Wei-Hui Zhang, Hong-Chi Jiang, An-Long Zhu, Lin-Feng Wu, Shu-Yi Qi, Da-Xun Piao, Arterial chemotherapy of 5-fluorouracil and mitomycin C in the treatment of liver metastases of colorectal cancer World Journal of Gastroenterology. ,vol. 8, pp. 663- 667 ,(2002) , 10.3748/WJG.V8.I4.663
Bohuslav Melichar, Pavel Jandík, Karolina Melicharová, Jaroslav Cerman, René Voboril, Zbynek Voboril, Jindriska Mergancová, Survival of patients with colorectal cancer liver metastases treated by regional chemotherapy. Hepato-gastroenterology. ,vol. 53, pp. 426- 434 ,(2006)
Hans Ehrsson, Marko Kornmann, Inger Wallin, Claudia Fester, Erkki Lotspeich, Irene Guthoff, Miriam Schatz, Hepatic artery infusion using oxaliplatin in combination with 5-fluorouracil, folinic acid and mitomycin C: oxaliplatin pharmacokinetics and feasibility. Anticancer Research. ,vol. 23, pp. 5203- 5208 ,(2003)
A. Baggiani, A. M. Ierardi, B. Caspani, F. Motta, D. Toniolo, P. Belloni, E. Setola, E. Campagnoli, S. Tempini, R. Crocchiolo, M. Bregni, L. Belli, Hypoxic liver perfusion with mitomycin-C for treating multifocal metastases and unresectable primary tumours: a single-centre series of 42 patients. Radiologia Medica. ,vol. 116, pp. 1239- 1249 ,(2011) , 10.1007/S11547-011-0724-3
Enzo Mammano, Simone Mocellin, Donato Nitti, Emanuela Tessari, Pierluigi Pilati, Mario Lise, Hepatic arterial infusion for unresectable colorectal liver metastases combined or not with systemic chemotherapy. Anticancer Research. ,vol. 29, pp. 4139- 4144 ,(2009)
L.B.J. Valkenburg-van Iersel, M. Koopman, C.J.H. van de Velde, L. Mol, P.J.K. Kuppen, A.L. Vahrmeijer, J.W.R. Nortier, R.A.E.M. Tollenaar, C. Punt, H. Gelderblom, 6054 Management of isolated non-resectable liver metastases in colorectal cancer patients: a case-control study of isolated hepatic perfusion with melphalan versus systemic chemotherapy Ejc Supplements. ,vol. 7, pp. 337- 338 ,(2009) , 10.1016/S1359-6349(09)71149-8
L Weiss, E Grundmann, J Torhorst, F Hartveit, I Moberg, Mea Eder, CM Fenoglio‐Preiser, J Napier, CHW Horne, MJ Lopez, RI Shaw‐Dunn, J Sugar, JD Davies, DW Day, JP Harlos, None, Haematogenous metastastic patterns in colonic carcinoma: An analysis of 1541 necropsies The Journal of Pathology. ,vol. 150, pp. 195- 203 ,(1986) , 10.1002/PATH.1711500308
Karl H. Link, Ellen Sunelaitis, Marko Kornmann, Miriam Schatz, Frank Gansauge, Gerd Leder, Andrea Formentini, Ludger Staib, J�rgen Pillasch, Hans G. Beger, Regional chemotherapy of nonresectable colorectal liver metastases with mitoxantrone, 5-fluorouracil, folinic acid, and mitomycin C may prolong survival. Cancer. ,vol. 92, pp. 2746- 2753 ,(2001) , 10.1002/1097-0142(20011201)92:11<2746::AID-CNCR10098>3.0.CO;2-Q