DNA origami delivery system for cancer therapy with tunable release properties.
作者： Yong-Xing Zhao , Alan Shaw , Xianghui Zeng , Erik Benson , Andreas M. Nyström
DOI: 10.1021/NN3022662
关键词:
摘要: In the assembly of DNA nanostructures, specificity Watson–Crick base pairing is used to control matter at nanoscale. Using this technology for drug delivery a promising route toward magic bullet concept, as it would allow realization complex assemblies that co-localize drugs, targeting ligands and other functionalities in one nanostructure. Anthracyclines' mechanism action cancer therapy intercalate DNA, since nanotechnology allows such high degree customization, we hypothesized us tune nanostructures optimal anthracycline doxorubicin (Dox) human breast cells. We have tested two origami on three different cell lines (MDA-MB-231, MDA-MB-468, MCF-7). The were designed exhibit varying degrees global twist, leading amounts relaxation double-helix structure. By tuning nanostructure design are ab...
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