Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny

摘要: // Saara Marttila 1,2 , Laura Kananen Juulia Jylhava Tapio Nevalainen Antti Hervonen 2,3 Marja Jylha 2,3,4 and Mikko Hurme 1,2,5 1 Department of Microbiology Immunology, School Medicine, University Tampere, Finland 2 Gerontology Research Center, 3 Health Sciences, 4 Institute for Advanced Social Research, 5 Fimlab Laboratories, Correspondence to: Marttila, email: Keywords : lifespan, longevity, DNA methylation, methylome, intergenerational inheritance, Gerotarget Received August 17, 2015 Accepted 27, Published September 30, Abstract The heritability lifespan is 20-30%, but only a few genes associated with longevity have been identified. To explain this discrepancy, the inheritance epigenetic features, such as proposed to contribute lifespan. We investigated whether parental methylation profile in nonagenarians. A regression model, adjusted differences blood cell proportions, identified 659 CpG sites where level was paternal However, no association observed between maternal methylation. were enriched outside islands located development morphogenesis, well signaling. largest difference progeny shortest-lived longest-lived fathers mapping CXXC5 . In addition, three Notch-genes ( NOTCH1 NOTCH3 NOTCH4 ) also There are implications acquired traits via mechanisms mammals. Here we describe features that speculate may represent inheritance.