Lumped-parameter modelling of cardiovascular system dynamics under different healthy and diseased conditions

摘要: Cardiovascular disease is the most common cause of death in modern society, and research into diagnosis treatment cardiovascular diseases an urgent task. Lumped-parameter mathematical modelling as efficient effective technique has been extensively applied dynamics research, achieved enormous success assisting physiology study. This thesis reports a coherent work lumped-parameter based on some selected works that author conducted published past several years. After critical comprehensive review concurrent technique, improved model effectively describes important features heart valve atrial-ventricular septum motion presented. The then adapted to study application cases typical failure condition with ventricular assist device support, extension for optimisation pulsatile bioreactor tissue engineering Some on-going future directions are also introduced. reported studies useful design prosthetic organs.