Mast cells are essential intermediaries in regulatory T-cell tolerance.

作者: Li-Fan Lu , Evan F. Lind , David C. Gondek , Kathy A. Bennett , Michael W. Gleeson

DOI: 10.1038/NATURE05010

关键词:

摘要: Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained in this study establish that mast cells are essential in CD4 + CD25 + Foxp3 + regulatory T (T …

参考文章(30)
Masaki Hara, Cherry I. Kingsley, Masanori Niimi, Simon Read, Stuart E. Turvey, Andrew R. Bushell, Peter J. Morris, Fiona Powrie, Kathryn J. Wood, IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo Journal of Immunology. ,vol. 166, pp. 3789- 3796 ,(2001) , 10.4049/JIMMUNOL.166.6.3789
Sergio A. Quezada, Kathy Bennett, Bruce R. Blazar, Alexander Y. Rudensky, Shimon Sakaguchi, Randolph J. Noelle, Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation. Journal of Immunology. ,vol. 175, pp. 771- 779 ,(2005) , 10.4049/JIMMUNOL.175.2.771
David C. Gondek, Li-Fan Lu, Sergio A. Quezada, Shimon Sakaguchi, Randolph J. Noelle, Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism Journal of Immunology. ,vol. 174, pp. 1783- 1786 ,(2005) , 10.4049/JIMMUNOL.174.4.1783
Yuhong Zhou, Michael McLane, Roy C Levitt, Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma Respiratory Research. ,vol. 2, pp. 80- 84 ,(2001) , 10.1186/RR42
Lamis Z. Jarvinen, Bruce R. Blazar, Oyedele A. Adeyi, Terry B. Strom, Randolph J. Noelle, CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance. Transplantation. ,vol. 76, pp. 1375- 1379 ,(2003) , 10.1097/01.TP.0000093462.16309.73
Michael J Townsend, Padraic G Fallon, David J Matthews, Philip Smith, Helen E Jolin, Andrew N.J McKenzie, IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development Immunity. ,vol. 13, pp. 573- 583 ,(2000) , 10.1016/S1074-7613(00)00056-X
Christophe Benoist, Diane Mathis, Mast cells in autoimmune disease Nature. ,vol. 420, pp. 875- 878 ,(2002) , 10.1038/NATURE01324
Shinichiroh Saitoh, Ramachandran Arudchandran, T.Scott Manetz, Weiguo Zhang, Connie L Sommers, Paul E Love, Juan Rivera, Lawrence E Samelson, LAT Is Essential for FcεRI-Mediated Mast Cell Activation Immunity. ,vol. 12, pp. 525- 535 ,(2000) , 10.1016/S1074-7613(00)80204-6