Stem cell division is regulated by the microRNA pathway.

摘要: The trademark property of stem cells is their capacity to multiply in tissues when other are quiescent. Somehow they by-pass the cell division stop signals. An experiment which microRNA processing was blocked Drosophila germline suggests that these gene-silencing regulatory molecules part a mechanism makes insensitive environmental signals normally at G1/S transition cycle. Without microRNAs, germ dividing just like ‘normal’ cells. Three papers last week's Nature highlighted role microRNAs human cancer: it possible unregulated tumour and regulation two sides same coin. On cover, lacking due over-production suppressor p21/p27. One key characteristics divide for long periods time an environment where most Therefore, critical question biology how escape Here, we report necessity (miRNA) pathway1,2,3,4 proper control (GSC) melanogaster. Analysis GSCs mutant dicer-1 (dcr-1), double-stranded RNaseIII essential miRNA biogenesis, revealed marked reduction rate cyst production. These dcr-1 exhibit normal identity but defective cycle control. basis markers genetic interactions, conclude delayed G1 S transition, dependent on cyclin-dependent kinase inhibitor Dacapo, suggesting miRNAs required bypass checkpoint. Hence, pathway might be transition.