Comparison of Glucagon and Epinephrine Effects in the Dog

摘要: Intravenous injection of 1–2 μg/kg glucagon produced greater and more persistent effects on liver glycogen blood glucose dogs than 10–50 epinephrine. When administration was by portal vein infusion, appeared to be 100 times as potent a glycogenolytic agent Epinephrine via the femoral when infused into vein; It is concluded that in dog, well rat, only can serve physiologic hepatic agent, effect moderate doses epinephrine an indirect one, possibly mediated through stimulation secretion. (Endocrinology 78: 47, 1966)