Feedforward Regulation Ensures Stability and Rapid Reversibility of a Cellular State

摘要: Summary Cellular transitions are important for all life. Such transitions, including cell fate decisions, often employ positive feedback regulation to establish and stabilize new cellular states. However, is unlikely underlie stable cell-cycle arrest in yeast exposed mating pheromone because the signaling pathway linear, rather than bistable, over a broad range of extracellular concentration. We show that stability pheromone-arrested state results from coherent feedforward inhibitor Far1. This network motif effectively isolated more complex regulatory which it embedded. Fast Far1 by phosphorylation allows rapid reentry, whereas slow synthesis reinforces arrest. expect be frequently implemented at reversible this can achieve ostensibly conflicting aims and rapid reversibility without loss information.