摘要: Few polymorphic plasma proteins have attracted more interest among scientists during the last ten years than Pi (protease inhibitor) system of human α1-antitrypsin (α1 AT). There are several reasons for this interest. The was, from beginning, associated with disease, which heralded possibility studying pathogenetic mechanism leading to tissue damage. With development high-resolution techniques, was soon shown comprise 30 codominant alleles. Several these alleles in many ethnic groups, thus providing a useful marker population geneticists. finding linkage between and Gm IgG has contributed chromosome mapping studies on crossing-over processes. may provide insight into selective forces.
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