Dearomatization of Indoles via a Phenol‐Directed Vanadium‐ Catalyzed Asymmetric Epoxidation and Ring‐Opening Cascade
作者： Long Han , Wei Zhang , Xiao-Xin Shi , Shu-Li You
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摘要: An enantioselective dearomatization of indole derivatives was realized by the complexes derived from vanadium complex VO(acac)2 and C2-symmetric bis-hydroxamic acid (BHA) ligands. The reaction proceeded via asymmetric epoxidation ring-opening linked phenol cascade, affording 5a,6,10b,11-tetrahydrochromeno[2,3-b]indol-10b-ol in up to 83% yield 98% ee under mild conditions.
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