Noradrenaline modulates decision urgency during sequential information gathering

摘要: Arbitrating between timely choice and extended information gathering is critical in effective decision making. Aberrant behaviour said to be a feature of psychiatric disorders such as schizophrenia obsessive-compulsive disorder. We know little about the neurocognitive control mechanisms that drive gathering. In double-blind placebo-controlled drug study with 60 healthy humans (30 female), we examined effects noradrenaline dopamine antagonism on show modulating function propranolol leads decreased this contrasts no effect following modulation function. Using Bayesian computational model, sampling best explained when including an urgency signal promotes commitment early decision. demonstrate blockade expression decision-related during discuss findings respect psychopathological conditions are linked aberrant