Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof

摘要: Surface-enhanced Raman spectroscopic (SERS) systems and methods for detecting biomolecules of interest, such as a virus, bacterium, or other infectious agent, are provided. A assay based on surface enhanced scattering using silver nanorod array substrate fabricated by oblique angle deposition has been developed that allows rapid detection trace levels viruses bacteria with high degree sensitivity specificity. This novel improved SERS can detect minor spectral differences within strains single virus type respiratory syncytial influenza in the presence biological media. The method provides diagnostics direct molecular structural characterization gene deletion mutants generating reproducible viral spectra without manipulation.