Methods of treating patients having mutations in the extracellular domain of epidermal growth factor receptor (EGFR) with a combination of three fully human monoclonal anti-EGFR antibodies
作者： Alberto Bardelli , Rachel C. Nering , Jeffrey David Kearns , Sabrina Arena , Hongfang Wang
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摘要: Provided herein are methods of treating an epidermal growth factor receptor (EGFR) extracellular domain (ECD) mutant cancer in a human patient by administering to the oligoclonal anti-epidermal (anti-EGFR) antibody combination (e.g., MM-151, comprising first monoclonal (P1X), second (P2X), and third (P3X),wherein P1X, P2X P3X 2:2: 1 molar ratio). In one embodiment, comprises at least mutation EGFR selected from group consisting R451C, S464L, K467T, G465R, G465E, 1491M, S492R.
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