Characterization of Mast Cell Activation Syndrome

摘要: Background Mast cell activation syndrome (MCAS), a recently recognized nonneoplastic mast disease driving chronic multisystem inflammation and allergy, appears prevalent thus important. We report the first systematic characterization of large MCAS population. Method Demographics, comorbidities, symptoms, family histories, physical examination laboratory findings were reviewed in 298 retrospective 115 prospective patients with MCAS. Blood samples from subjects examined by flow cytometry for clonal tested cytokines potentially monocytosis frequent Results Demographically, white females dominated. Median ages at symptom onset diagnosis 9 49 years, respectively (range: 0-88 16-92, respectively) median time to was 30 years 1-85). numbers medical issues 11, 20, 4, 1-66, 2-84, 0-33, respectively). Gastroesophageal reflux, fatigue dermatographism most common comorbidity, finding. Abnormalities routine laboratories diverse but typically modest. The useful diagnostic markers heparin, prostaglandin D2, histamine chromogranin A. Flow cytometric cytokine assessments unhelpful. Conclusions Our study highlights MCAS׳s morbidity burden challenging heterogeneity. Recognition is important given good survival treatment prospects.