Serum Ceramides as Prognostic Biomarkers of Large Thrombus Burden in Patients with STEMI: A Micro-Computed Tomography Study.

摘要: ST-elevation myocardial infarction (STEMI) remains one of the leading causes mortality worldwide. The identification novel metabolic and imaging biomarkers could unveil key pathophysiological mechanisms at molecular level promote personalized care in patients with acute coronary syndromes. We studied 38 STEMI who underwent primary percutaneous intervention thrombus aspiration. sought to correlate serum ceramide levels micro-CT quantified aspirated volume relevant angiographic outcomes, including modified TIMI grade pre- or post-procedural flow. Higher C16:0 were significantly but weakly correlated larger (Spearman r = 0.326, p 0.046), intracoronary burden (TB; 0.030) worse flow (p 0.049 0.039, respectively). Ceramides C24:0 C24:1 also associated TB 0.008 0.001, Receiver operating characteristic analysis demonstrated that ceramides predict higher (area under curve: 0.788, 95% CI: 0.629-0.946 0.846, 0.706-0.985, In conclusion, among TB. This suggests quantification might improve risk-stratification facilitate an individualized approach clinical practice.