作者: I. M. Lee , H. D. Sesso , R. S. Paffenbarger
DOI: 10.1093/IJE/28.4.620
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摘要: Background Physical activity has been proposed to decrease lung cancer risk; however, few data are available. Further, no studies have examined specific kinds and intensities of activities. Methods We conducted a prospective cohort study among 13 905 male Harvard University alumni (mean age, 58.3 years), free cancer. Men reported their walking, stair climbing participation in sports or recreation on baseline questionnaires 1977, the occurrence follow-up 1988 1993. Death certificates were obtained for decedents through 1992 determine cancers not previously reported. Results During follow-up, 245 men developed Adjusting cigarette smoking, body mass index, relative risks associated with ,4200, 4200‐8399, 8400‐12 599 >12 600 kJ/week estimated energy expenditure at 1.00 (referent), 0.87 (95% CI : 0.64‐1.18), 0.76 0.52‐1.11), 0.61 0.41‐0.89), respectively; P trend = 0.0008. Similar trends observed non-smokers former smokers 1977 (82.7% men) as well those who smoked .20 cigarettes day (8.0%), although findings latter group statistically significant, possibly due small number. Walking, stairs participating activities least moderate intensity (>4.5 MET, multiples resting metabolic rate) each inversely risk, independent other components. However, light (,4.5 MET) did predict risk. Conclusions These indicate that physical may be lower risk men. An 12 kJ/week, achievable by perhaps 6‐8 hours activity, significantly Further required confirm these observations.