Physical activity and risk of lung cancer.

作者: I. M. Lee , H. D. Sesso , R. S. Paffenbarger

DOI: 10.1093/IJE/28.4.620

关键词:

摘要: Background Physical activity has been proposed to decrease lung cancer risk; however, few data are available. Further, no studies have examined specific kinds and intensities of activities. Methods We conducted a prospective cohort study among 13 905 male Harvard University alumni (mean age, 58.3 years), free cancer. Men reported their walking, stair climbing participation in sports or recreation on baseline questionnaires 1977, the occurrence follow-up 1988 1993. Death certificates were obtained for decedents through 1992 determine cancers not previously reported. Results During follow-up, 245 men developed Adjusting cigarette smoking, body mass index, relative risks associated with ,4200, 4200‐8399, 8400‐12 599 >12 600 kJ/week estimated energy expenditure at 1.00 (referent), 0.87 (95% CI : 0.64‐1.18), 0.76 0.52‐1.11), 0.61 0.41‐0.89), respectively; P trend = 0.0008. Similar trends observed non-smokers former smokers 1977 (82.7% men) as well those who smoked .20 cigarettes day (8.0%), although findings latter group statistically significant, possibly due small number. Walking, stairs participating activities least moderate intensity (>4.5 MET, multiples resting metabolic rate) each inversely risk, independent other components. However, light (,4.5 MET) did predict risk. Conclusions These indicate that physical may be lower risk men. An 12 kJ/week, achievable by perhaps 6‐8 hours activity, significantly Further required confirm these observations.

参考文章(23)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Jay H. Lubin, William J. Blot, Assessment of Lung Cancer Risk Factors by Histologic Category JNCI: Journal of the National Cancer Institute. ,vol. 73, pp. 383- 389 ,(1984) , 10.1093/JNCI/73.2.383
Richard A. Washburn, Kevin W. Smith, Sheila R.W. Goldfield, John B. McKinlay, Reliability and physiologic correlates of the harvard alumni activity survey in a general population Journal of Clinical Epidemiology. ,vol. 44, pp. 1319- 1326 ,(1991) , 10.1016/0895-4356(91)90093-O
JEFFREY A. WOODS, J MARK DAVIS, Exercise, monocyte/macrophage function, and cancer Medicine and Science in Sports and Exercise. ,vol. 26, pp. 147- 156 ,(1994) , 10.1249/00005768-199402000-00004
BENTE KLARLUND PEDERSEN, HENRIK ULLUM, NK cell response to physical activity: possible mechanisms of action Medicine and Science in Sports and Exercise. ,vol. 26, pp. 140- 146 ,(1994) , 10.1249/00005768-199402000-00003
D Albanes, A Blair, P R Taylor, Physical activity and risk of cancer in the NHANES I population. American Journal of Public Health. ,vol. 79, pp. 744- 750 ,(1989) , 10.2105/AJPH.79.6.744
BARBARA E. AINSWORTH, WILLIAM L. HASKELL, ARTHUR S. LEON, DAVID R. JACOBS, HENRY J. MONTOYE, JAMES F. SALLIS, RALPH S. PAFFENBARGER, Compendium of physical activities: classification of energy costs of human physical activities. Medicine and Science in Sports and Exercise. ,vol. 25, pp. 71- 80 ,(1993) , 10.1249/00005768-199301000-00011
Demetrius Albanes, Joan M. Conway, Philip R. Taylor, Paul W. Moe, Joseph Judd, Validation and comparison of eight physical activity questionnaires. Epidemiology. ,vol. 1, pp. 65- 71 ,(1990) , 10.1097/00001648-199001000-00014
Lawrence Garfinkel, Steven D. Stellman, Mortality by relative weight and exercise Cancer. ,vol. 62, pp. 1844- 1850 ,(1988) , 10.1002/1097-0142(19881015)62:1+<1844::AID-CNCR2820621328>3.0.CO;2-O
S. H. Landis, T. Murray, S. Bolden, P. A. Wingo, Cancer statistics, 1998 CA: A Cancer Journal for Clinicians. ,vol. 48, pp. 6- 29 ,(1998) , 10.3322/CANJCLIN.48.1.6