NADPH oxidase contributes to the left ventricular dysfunction induced by sinoaortic denervation in rats.
作者： L. Zhang , F. Li , G. Zhi , B. Zhang , Y.-D. Chen
DOI: 10.3109/10715762.2014.978768
关键词:
摘要: AbstractThe aim of this work was to investigate the role nicotinamide adenine dinucleotide phosphate (NADPH) oxidase on left ventricular dysfunction rats submitted sinoaortic denervation (SAD). Experiment 1: 8 weeks after SAD rats, NADPH in ventricles assayed by Western blotting analysis. 2: Rats were subjected and received treatment with apocynin (an inhibitor, 30 mg/kg/day, intragastric administration) for weeks; SAD, Nox2 Nox4 expressions Rac1 activity higher than those sham-operated rats. Although did not affect blood pressure, pressure variability (BPV), baroreflex function, it significantly attenuated hypertrophy marked reduced expression atrial natriuretic factor β-myosin heavy chain. Treatment abated oxidative stress malondialdehyde formation suppressed nuclea...
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