The potential of LINGO-1 as a therapeutic target for essential tremor
作者： José AG Agúndez , Félix Javier Jiménez-Jimenez , Hortensia Alonso-Navarro , Elena García-Martín
DOI: 10.1517/14728222.2015.1028360
关键词:
摘要: Introduction: LINGO-1 is a negative regulator of neuronal survival, oligodendrocyte differentiation and axonal outgrowth regeneration, because it interacts with diverse growth factor receptors blocking or inhibiting their action. Consistent findings obtained in vitro animal models suggest that anti-LINGO-1 therapy may be useful neurodegenerative disorders such as multiple sclerosis (MS), Parkinson’s disease essential tremor (ET). Moreover, genetic pathological evidence provide robust link between ET.Areas covered: In this review, we present an overview current knowledge on linking ET, special focus linkage, include LINGO1 gene variations according to the 1000 genomes catalog, identify potential areas where common changes occur because, well risk developing influence response therapy.Expert opinion: The goal neurod...
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