Strategy of STAT3β cell-specific expression in macrophages exhibits antitumor effects on mouse breast cancer
作者： W Dang , H Tang , H Cao , L Wang , X Zhang
DOI: 10.1038/GT.2015.70
关键词:
摘要: Recent studies underscore the importance of crosstalk between tumor-associated macrophages (TAMs) and tumor cells in cancer progression metastasis. In our study, AdCD68STAT3β, a recombinant adenovirus containing STAT3β gene driven by CD68 macrophage-specific promoter, was used to suppress STAT3 downstream signaling pathways TAMs. The results showed that under control promoter only expressed macrophages, which significantly inhibited motility invasion breast when co-cultured with 4T1 cells. Moreover, cell-specific expression TAMs extended survival tumor-bearing mice suppressed growth, angiogenesis metastasis, regulating Therefore, study provided novel strategy for antitumor effects STAT3β.
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