Determinants of losses in the latent tuberculosis cascade of care in Brazil: A retrospective cohort study.

摘要: Abstract Background The present study evaluated factors associated with losses in the latent tuberculosis infection (LTBI) cascade of care contacts (TB) patients, a referral center from highly endemic region Brazil. Methods Contacts 1672 TB patients were retrospectively studied between 2009 and 2014. Data on screening by clinical investigation, radiographic examination tuberculin skin test (TST) extracted medical records. Losses incidence within 2-year follow-up calculated. Results From total 1180 initially identified, only 495 examined (58% loss), 20 diagnosed active at this stage. Furthermore, 435 persons returned for TST result interpretation 351 (∼81%) positive. Among those positive TST, 249 (73%) treated isoniazid 6 months whereas 51 abandoned therapy early. Three individuals who did not receive LTBI treatment, one incomplete treatment another completed developed TB. A logistic regression analysis revealed that increases age independent other epidemiological characteristics. Conclusions Major occur initial stages older are higher risk completing care.