Neutrophil Proteases Associated with Amyloid Fibrils

摘要: Abstract We found significant amounts of enzymatic activity characteristic the human neutrophil proteases, elastase and cathepsin G, associated with isolated amyloid fibrils from patients five different types systemic amyloidosis. Amyloid deposits in tissue sections A, transthyretin β2-microglobuhn amyloidosis also stained positive antiserum to G. Elastase azurophilic granules and, a lesser extent, monocyte, may become precursor proteins before or during formation fibrils. This occur an extracellular inflammatory microenvironment phagolysosome play role