Anti-inflammatory effects of opioids.

摘要: In summary, therapy with opioids is an exciting new development for arthritis especially since there the potential fewer side effects from molecules which act outside CNS. We found kappa-opioid drugs to be powerfully anti-inflammatory, reducing disease severity by as much 80%; attenuating in a dose-dependent, stereoselective, antagonist-reversible manner. By contrast acting at other receptors were only therapeutic near toxic doses. The HPA-axis was partially involved, thus we investigated neural and immune mechanisms. Results showed that anti-inflammatory actions exerted via (i) reduced adhesion molecule expression; (ii) inhibition of cell trafficking; (iii) TNF release expression (iv) alterations mRNA protein levels SP CGRP joint tissue (Fig. 2). ability kappa-opioids multiple sites inflammatory cascade, suggested presence opioid various locations throughout may explain their powerful It also relevant during states enhanced peripherally directed axonal transport leads receptor upregulation on peripheral nerve terminals joint. Neuropeptides (SP CGRP) involved later phases adjuvant suggesting they are maintenance or persistence disease. involvement efficacy neurokinin-1 receptors) antagonists predicts combined opioid- has promise. Kappa-opioids are, however, onset. Thus, most likely exert changes cellular activation cytokine expression. mechanisms summarized Fig. 2. increased potency females significant advantage treatment these agents. Thus our work supports findings Stein's group, do indeed have periphery specific site. Peripherally prove potent rheumatoid sufferers future.