Safety and efficacy of NT, an herbal supplement, in treating human obesity.

摘要: A human pilot study testing the safety and effectiveness of NT (Number Ten), a dietary herbal supplement made from rhubarb, ginger, astragulus, red sage turmeric, to reduce food intake cause weight loss. total 24 healthy women, 18–60 years, body mass index 25–35 kg/m2 on no chronic medication were randomized four groups six: (1) oral freeze-dried 6 gm/day, (2) bed-dried (3) 12 gm/day or (4) placebo. Number Ten dose was escalated over 3 weeks maintained for 8 700 kcal/day diet below maintenance. Food measured at baseline 4 weeks. Safety parameters monitored weekly during escalation, week 6 12. Weight loss 1.8 kg placebo 0.4 kg 500 mg whereas 250 mg bed- gained 0.43 0.87 kg, respectively (P=NS). The increased 74 kcal with decreased 193.7 kcal (P<0.01). There dose-related incidence loose stools in groups, but other toxicity seen. found contain sennosides, known laxatives gallic acid, which is give rodents. equivalent used this f that shown well-tolerated will not be an effective treatment obesity owing dose-limiting gastrointestinal toxicity.