Virulence as a target for antimicrobial chemotherapy.
作者： Lefa E Alksne
DOI: 10.1517/13543784.11.8.1149
关键词:
摘要: Bacterial resistance to present day antibiotics has become a dangerous threat public health. Consequently, the pharmaceutical industry must provide new agents and novel classes combat bacterial disease stay step ahead of rapid evolution mechanisms. The need for antibacterials resulted in search previously unexplored targets chemotherapy, utilising techniques genomics identify them. Several currently under investigation are involved process virulence. These unique that their inhibition, by definition, should interfere with infection rather than viability. If successful, virulence inhibition may represent ‘kinder, gentler’ approach chemotherapy which pathogen is disarmed killed outright.
informapharmascience.com参考文章(96)
Sylvie E. Blondelle, Susan M. Collins, Michael C. Davis, Helana D. McKeever, Richard A. Houghten, Christian N. Parker, Siddhartha Roychoudhury, Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase. Molecular Diversity. ,vol. 4, pp. 173- 182 ,(1998) , 10.1023/A:1009695718427
Michiko E. Taga, Julia L. Semmelhack, Bonnie L. Bassler, The LuxS‐dependent autoinducer AI‐2 controls the expression of an ABC transporter that functions in AI‐2 uptake in Salmonella typhimurium Molecular Microbiology. ,vol. 42, pp. 777- 793 ,(2008) , 10.1046/J.1365-2958.2001.02669.X
Sarkis K Mazmanian, Gwen Liu, Hung Ton-That, Olaf Schneewind, Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall Science. ,vol. 285, pp. 760- 763 ,(1999) , 10.1126/SCIENCE.285.5428.760
Michael W. Climo, Hospital-wide Restriction of Clindamycin: Effect on the Incidence of Clostridium difficile-Associated Diarrhea and Cost Annals of Internal Medicine. ,vol. 128, pp. 989- 995 ,(1998) , 10.7326/0003-4819-128-12_PART_1-199806150-00005
Robert D Perry, Signature-tagged mutagenesis and the hunt for virulence factors Trends in Microbiology. ,vol. 7, pp. 385- 388 ,(1999) , 10.1016/S0966-842X(99)01582-6
Antoine de Saizieu, Ulrich Certa, Janet Warrington, Christopher Gray, Wolfgang Keck, Jan Mous, Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays Nature Biotechnology. ,vol. 16, pp. 45- 48 ,(1998) , 10.1038/NBT0198-45
Tové C. Bolken, Christine A. Franke, Kevin F. Jones, Gloria O. Zeller, C. Hal Jones, Emma K. Dutton, Dennis E. Hruby, Inactivation of the srtA Gene in Streptococcus gordonii Inhibits Cell Wall Anchoring of Surface Proteins and Decreases In Vitro and In Vivo Adhesion Infection and Immunity. ,vol. 69, pp. 75- 80 ,(2001) , 10.1128/IAI.69.1.75-80.2001
Dario E Lehoux, François Sanschagrin, Roger C Levesque, Discovering essential and infection-related genes. Current Opinion in Microbiology. ,vol. 4, pp. 515- 519 ,(2001) , 10.1016/S1369-5274(00)00244-7
Hung Ton-That, Sarkis K Mazmanian, Olaf Schneewind, An embarrassment of sortases – a richness of substrates? Response Trends in Microbiology. ,vol. 9, pp. 101- 102 ,(2001) , 10.1016/S0966-842X(01)01955-2
Roy Magnuson, Jonathan Solomon, Alan D. Grossman, Biochemical and genetic characterization of a competence pheromone from B. subtilis Cell. ,vol. 77, pp. 207- 216 ,(1994) , 10.1016/0092-8674(94)90313-1