Universal genotyping in tuberculosis control program, New York City, 2001-2003.
作者： Carla M. Clark , Cynthia R. Driver , Sonal S. Munsiff , Jeffrey R. Driscoll , Barry N. Kreiswirth
关键词:
摘要: In 2001, New York City implemented genotyping to its tuberculosis (TB) control activities by using IS6110 restriction fragment length polymorphism (RFLP) and spoligotyping type isolates from culture-positive TB patients. Results are used identify previously unknown links among genotypically clustered patients, unidentified sites of transmission, potential false-positive cultures. From 2001 2003, spoligotype IS6110-based RFLP results were obtained for 90.7% eligible 93.7% submitted isolates. Fifty-nine (2.4%) 2,437 patient had culture results, 205 genotype clusters identified, with 2–81 cases per cluster. Cluster investigations yielded 57 additional 17 transmission. Four identified as a result case finding initiated through cluster investigations. Length unnecessary treatment decreased patients
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