Impairment in complex activities of daily living is related to neurodegeneration in Alzheimer's disease–specific regions

摘要: Impairment in instrumental activities of daily living (IADL) is an early clinical feature Alzheimer's disease (AD). The neurobiology underlying IADL disruptions still unclear. We aimed to investigate the relationship between functioning and cortical atrophy across AD spectrum. selected 162 memory-clinic subjects with subjective cognitive decline (n = 49), mild impairment 26) or dementia 87), available structural MRI acquired at 3.0 Tesla Amsterdam Questionnaire (A-IADL-Q) assessment. used linear regression correcting for age, sex, education, vascular injuries, total intracranial volume association gray matter A-IADL-Q score, voxel-based morphometry whether any associations were specific distinct regions. Less was associated lower scores (β 0.346, 95% CI [0.185-0.507], p < 0.001), specifically regions covering medial temporal lobes, cingulate cortex, precuneus (all p(familywise error-corrected) 0.05). Results similar when repeating analyses amyloid-positive 78). Our findings illustrate that detects functional related AD-specific neurodegeneration.