The role of complement in the localization of pneumococci in the splanchnic reticuloendothelial system during experimental bacteremia.

摘要: Pneumococci activate the alternative complement (C) pathway in absence of demonstrable antibody normal guinea pig serum. They also classical C presence type-specific and perhaps through other mechanisms as well. A quantitative examination was undertaken roles these 2 pathways activation splanchnic sequestration 125I-labeled pneumococci, using a-guinea model pneumococcal bacteremia. Normal unimmunized pigs (NIH-GP) localized more than 3 times many pneumococci to liver spleen during a period when exponential bloodstream clearance occurring. C4-deficient (C4D-GP) cobra venom factor-treated (CVF-GP) showed progressively fewer cleared by with concomitant increases extent splenic uptake, demonstrating important role bacteria animal. Immunization brought about an increase NIH C4D-GP but did not affect localization pattern CVF-GP. comparison reticuloendothelial system (RES) patterns rate removal from highly significant correlation between persistence Thus, opsonization is determinant RES pneumococci. Unlike RBC clearance, where plus IgM leads hepatic localization, IgG tends produce or cause When C-mediated opsonic activity less optimal, slower bacteremia that results accompanied increased dependence on