Maternal microchimerism protects against the development of asthma.

摘要: Background Maternal asthma and child's sex are among the most significant reproducible risk factors for development of asthma. Although mechanisms these effects unknown, they likely involve nonclassical genetic mechanisms. One such mechanism could transfer persistence maternal cells to her offspring, a common occurrence known as microchimerism (MMc). MMc has been associated with many autoimmune diseases but not investigated role in or allergic disease. Objective We hypothesized that some observed risks may be due different rates transmission children mothers compared without asthma, sons daughters. further differ between Methods tested hypotheses 317 subjects from 3 independent cohorts by using real-time quantitative PCR assay detect noninherited HLA allele child. Results was detected 20.5% (range 16.8%-27.1% cohorts). lower MMc-positive than MMc-negative (odds ratio, 0.38; 95% CI, 0.19-0.79; P  = .029). Neither nor child predictor (  = .81 .15, respectively). Conclusions Our results suggest first time protect against